Purpose: The SAGIT instrument is a comprehensive clinician-reported outcome instrument assessing key features of acromegaly: signs and symptoms, associated comorbidities; growth hormone levels; insulin-like growth factor-1 levels; and tumor profile. Here, we report on pre-testing to assess ease of understanding and acceptability and a pilot study to assess relevance, ease of use, and utility in real-life conditions NCT Methods: For pre-testing, 11 endocrinologists completed the SAGIT instrument using patient medical records and were also interviewed. Results: The SAGIT instrument was well accepted by endocrinologists, with most indicating that it was concise, practical, easy to understand, useful for assessing treatment response, and valuable as a component of the patient's medical record. The pilot study confirmed the instrument's acceptability, utility, and ease of use, and indicated its potential for distinguishing acromegaly clinical stages.
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Cardiovascular disturbances in acromegaly. Acromegaly causes a number of disorders in the cardiovascular system, resulting from chronic exposure to high levels of GH and IGF Such disorders are the main responsible for increased mortality rates among acromegalic patients.
Among several forms of cardiovascular impairment is acromegalic cardiomyopathy, an entity that is initially characterized by a hyperdynamic state, followed by concentric left ventricular hypertrophy and diastolic dysfunction due to relaxation deficit, culminating in systolic dysfunction and sometimes heart failure. In addition, arrhythmias and heart valve diseases are also relevant, especially mitral and aortic, ischemic heart disease, hypertension, and glucose and lipid metabolism disorders.
This review approaches the main clinical and prognostic aspects of these entities, the effects of acromegaly treatment on them, and the respective consequences on patient survival.
Keywords: Acromegaly; Acromegalic cardiomyopathy; Secondary hypertension; Cardiovascular risk. Os efeitos do excesso de GH e IGF-1 sobre o crescimento acral e visceral e sobre o metabolismo ocorrem insidiosamente. No recente estudo do Registro Espanhol de Acromegalia ocorreram 56 mortes em 1.
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Villabona coordinador , M. Lucas, B. Moreno, G. Obiols, C.