Optofluidics is an emerging field that involves the use of fluids to modify optical properties and the use of optical devices to detect flowing media. Ultimately, its value is highly dependent on the successful integration of photonic integrated circuits with microfluidic or nanofluidic systems. Handbook of Optofluidics provides a snapshot of the state of the field, captures current trends, and gives insight into the technology of tomorrow, which will enable researchers to tackle challenges and opportunities that it can uniquely answer. Divided into three sections, this comprehensive resource begins by introducing the scientific foundations that contribute to optofluidics.
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Handbook of Photonics for Biomedical Engineering pp Cite as. Optofluidic lab-on-a-chip LOC devices have drawn significant attention because of their special attraction to point-of-care applications. In this chapter, the advancement and key accomplishments of LOC devices that utilize optics as means to detect biomedical signals are discussed. The topics being covered include optofluidic waveguide designs, detection techniques, and various optofluidic LOC systems and experimental demonstration.
Limited by the fabrication and material issues, most LOC devices produce lower signal quality than their large-size counterparts. Therefore, improving the signal quality and detection sensitivity of LOC devices is of tremendous importance to find their clinical applications.
To this end, novel techniques that combine the optical-coding method with 3-D flow confinement designs are discussed. The optical-coding method enables us to use digital signal processing to enhance the signal-to-noise ratio, while the 3-D flow focusing designs help reduce variations in cell distribution inside the channel, thus removing some major sources of signal fluctuations.
Besides a review of key efforts and accomplishments in the field, this chapter also points out promising pathways toward low-cost, high-performance optofluidic LOC systems for point-of-care clinics.
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Lab-on-a-Chip Device and System for Point-of-Care Applications
Handbook of Optofluidics