Management of children with Guillain-Barre syndrome. Jones HR Jr. Guillain-Barre syndrome: perspectives with infants and children. Semin Pediatr Neurol ; 7 2 : Beghi E et al. Guillain-Barre syndrome.
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Síndrome de Guillain-Barré
The demyelinating form of Guillain-Barre syndrome destroys the protective covering of the peripheral nerves myelin sheath , preventing the nerves from transmitting signals to the brain. Weakness and tingling in your extremities are usually the first symptoms. These sensations can quickly spread, eventually paralyzing your whole body. In its most severe form Guillain-Barre syndrome is a medical emergency. Most people with the condition must be hospitalized to receive treatment. The exact cause of Guillain-Barre syndrome is unknown. But two-thirds of patients report symptoms of an infection in the six weeks preceding.
Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. In those with severe weakness, prompt treatment with intravenous immunoglobulins or plasmapheresis , together with supportive care, will lead to good recovery in the majority of people. This is followed by weakness of the legs and arms that affects both sides equally and worsens over time. The plateau phase can take between two days and six months, but the most common duration is a week. This may consist of upper respiratory tract infection rhinitis, sore throat or diarrhea.